WebJun 1, 1997 · The indirect comparison showed substantial increased benefit from the former (odds ratio 0.37, 95% CI 0.21 to 0.65), while direct comparisons from randomized trials suggests a much smaller difference (risk ratio 0.64, 95% CI 0.45 to 0.90; p -value for difference of effect = 0.11). Direct comparisons of treatments should be sought.

NICE guidance on dapagliflozin for chronic heart failure with …

WebIndirect comparisons In absence of direct evidence for treatments A vs B, an indirect estimate of log risk ratio lrr ABcan be obtained from RCTs comparing A vs C and B vs C: LRR AB =LRR AC tLRR BC A B C *Bucher HC, et al.(1997); Glenny et al (2005) Slide 9 9 *Bucher HC, et al.(1997); Glenny et al (2005) Indirect comparisons WebBucher et al.(1997) discussed the example case of thecomparison of sulphametoxazole-trimethoprim (TMP-SMX)versusdapsone/pyrimethamine (D/P)for the prophylaxis … nike headquarters hilversum

A Systematic Literature Review and Bucher Indirect Comparison

WebNov 10, 2010 · Indirect comparisons based on non-randomised trials. Reviews that indirectly compared interventions qualitatively (i.e. did not apply statistical methods). … WebIndirect comparison is often used because of a lack of, or insufficient, evidence from head-to-head comparative trials. ... Bucher and colleagues suggested a simple method of adjusted indirect comparison, in which the indirect comparison of A and B is adjusted according to the results of their direct comparisons with a common WebThe unadjusted HR for RIBO versus PALBO was 0.918 (0.492; 1.710) while MAIC produced an HR of 0.839 (0.440; 1.598). The HR results of this analysis are presented in Figure 2. Figure 2 Overall survival for RIBO versus PALBO with and without matching adjustment. Notes: HR <1 favors RIBO, >1 favors PALBO. nike headquarters location