Circpvt1 review
WebThis review summarizes various pathways through which PVT1 regulates the progression of cancer via miRNAs. We also propose additional regulatory mechanisms of PVT1 and their potential clinical applications. ... The circular PVT1 (circPVT1) locus is contained within the lncPVT1, which originates from the exon 2 of the PVT1 gene. Several studies ... WebThe only slight annoyance was that they increased their PCR tests by £20 just recently on time for holiday travel. PCR tests should be much cheaper now after almost 3 years of …
Circpvt1 review
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WebOct 15, 2024 · b The circPVT1 was markedly up-regulated in EC tissues compared with the adjacent tissues. **P < 0.01; n = 20. c The level of circPVT1 was significantly increased in cancer cell lines, especially in EC109, TE-1 and TE-10. **P < 0.01; n = 3. d The circPVT1 levels decreased significantly when TE-1 cells were maintained to over-confluence. WebAug 11, 2024 · Results. circPVT1 and TRIAP1 were highly expressed, and miR-137 was decreased in DXR-resistant osteosarcoma tissues and cells. Moreover, circPVT1 knockdown could boost DXR sensitivity by inhibiting DXR-caused proliferation and DXR-induced apoptosis in DXR-resistant osteosarcoma cells in vitro.
WebDec 20, 2024 · Using samples from 115 HNSCC patients, we find that circPVT1 is over-expressed in tumors compared to matched non-tumoral tissues, with particular enrichment in patients with TP53 mutations. circPVT1 up- and down-regulation determine, respectively, an increase and a reduction of the malignant phenotype in HNSCC cell lines. WebNov 1, 2024 · CircPVT1 was able to enhance NF-κB signal pathway's expression through reducing miR-125b. Conclusions: CircPVT2 can promote ALL cell proliferation and invading through miR-125b modulation of...
WebFeb 16, 2024 · CircPVT1 was over-expressed in OS tissues and cells, and correlated with clinical features of OS. Over-expressed circPVT1 reduced the survival of OS patients. CircPVT1 was up-regulated in chemoresistant OS cells compared to their parental cells. CircPVT1 inhibition suppressed the proliferation and chemoresistance of OS cells. WebAug 8, 2024 · This Review describes recent progress in our understanding of the biogenesis and biology of circRNAs and delineates modern technologies that will further advance …
WebJun 10, 2024 · CircPVT1 promotes LUSC progression via HuR/circPVT1/miR-30d and miR-30e/CCNF cascade. Also, it acts as a novel diagnostic biomarker or treatment target of individuals diagnosed with LUSC. Background Lung cancer (LC) accounts for the highest rate of cancer incidence and mortalities across the globe.
WebApr 1, 2024 · circPVT1 and lncPVT1 shared features and functions in human cancer cells. Pathways regulated by both circPVT1 and lncPVT1 in cancer, as documented in the … unc chancellor org chartWebMore importantly, circPVT1 was predominantly abundant in the cytoplasm of NSCLC cells, and circPVT1 could serve as a competing endogenous RNA to regulate E2F2 expression and tumorigenesis in a miR-125b-dependent manner, which is further verified by using an in vivo xenograft model. Conclusion: thorogood 864-4078WebCircPVT1 as potential clinical biomarker. Although studies on circPVT1 in malignancy remained scanty, significant association of the candidate with disease onset and outcome indicated it as a promising biomarker of … thorogood 864-4278WebJan 28, 2024 · Here, we review circPVT1 origin and biogenesis highlighting the most important mechanisms through which it plays a fundamental role in oncogenesis, such … unc chapel hill act range 2022WebApr 1, 2024 · CircPVT1, as an oncogenic circRNA, has been found to be upregulated in various human cancers, such as GC, CRC, BCa, and osteosarcoma. 15, 16, 20 It has … thorogood 864-4280WebCircPVT1 has been found to increase proliferation of gastric cancer cell through serving as a molecular sponge for miR-125 family members . Moreover, expression of circPVT1 … unc chapel hill 101 manning dr chapel hillWebCircular PVT1: an oncogenic non-coding RNA with emerging clinical ... thorogood 867-0108