Klf2 and t cell activation

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August undefined, 2024

WebJul 1, 2014 · We now report that transcription factor Krüppel-like factor 2 (KLF2) is necessary for the generation of iTregs but not tTregs. Moreover, drugs that limit KLF2 … WebChimeric antigen receptor (CAR) T cell therapy has emerged as a new opportunity for cancer treatment; however, resistance can occur due to intrinsic (T cells), extrinsic (tumors), or acquired (tumors) factors. In many cases, the knowledge of these mechanisms comes from clinical observations of patients treated with CAR T cells. In addition, the structure of the …

AKT activity orchestrates marginal zone B cell development in …

Webof differential expression in CD4+ T cells. In particular, KLF3, ZIC1, KLF2, Sp4, KLF12, and IRF2 are expressed in unstimu-lated CD4+ T cells relative to activated cells, while KLF4, ... signaling, Wnt, TGF-β, T-cell activation, and p53 (Fig. 2B). Pathways, such as p53, Toll-like receptor signaling, and Jak/ STAT signaling, have been linked to ... WebApr 4, 2006 · Lung KLF (LKLF; KLF2) has been shown to regulate T cell activation. KLF2 is induced during the maturation of single-positive T cells and is rapidly extinguished after single-positive T cell activation . Forced overexpression of KLF2 induced a quiescent T cell phenotype whereas KLF2-null T cells exhibited a spontaneously activated phenotype . c9300 data sheets

Dendritic Cell KLF2 Expression Regulates T Cell Activation and ...

WebNov 11, 2010 · KLF2 was initially found in T cells to maintain the quiescent state of single-positive CD4+or CD8+T cells.22,25KLF2 also inhibits Jurkat T-cell growth by inhibiting … WebSep 15, 2008 · Consistent with this, Klf2 has been shown to be induced downstream of ERK5 activation in endothelial cells 40. In T cells, the role of Klf2 has been assessed by using either Klf2 knockout embryonic stem 41 or foetal liver cells 42 to generate chimeras with Rag2 −/− blastocysts. These studies showed that while Klf2 was not essential for the ... WebNov 19, 2010 · Kruppel-like factor 2 (KLF2) is a transcription factor which has been shown to be a critical regulator of T lymphocyte quiescence and trafficking. KLF2 is highly expressed in naïve CD8 T cells but its expression is transcriptionally downregulated in effector cytotoxic T lymphocytes (CTL). c9300 cables in back

KLF2 is a clinical diagnostic and treatment ... - Semantic …

VISTA is a checkpoint regulator for naïve T cell quiescence and ...

WebTo date, both KLF2 and KLF13 have been shown to be involved in the regulation of development of T cells. Expression of KLF2 is downregulated following treatment of T … WebMay 29, 2014 · In summary, retrovirally transduced KLF2 leads to increased levels of the cell cycle inhibitor proteins p21 and p27 and decreased levels of c-myc, resulting in a severe block of pre-BCR-induced proliferation. KLF2 is expressed in mature, resting B cells, downregulated in activated B cells and reexpressed in memory B cells [17], [18], [19], [20]. c9300 dna advantage 24-port 3 year terWebOct 14, 2013 · The loss of KLF2 is thus a key part of the transcriptional program that directs the trafficking of activated T cells away from lymphoid tissue and promotes their extravasation to peripheral tissues. Moreover, KLF2 is required to repress cytokine production by naïve T cells [ 17 ]. clover crush

"WebMar 1, 2024 · KLF2, a member of the Kruppel-like factor family, has diverse roles in the immune system, and in particular plays a critical role in controlling migration of T (and B) … " - Klf2 and t cell activation

Klf2 and t cell activation

WebThe emerging role of KLF2 in regulation of osteoclastic differentiation is examined, specifically in the context of rheumatoid arthritis in which it has been most extensively studied among the musculoskeletal diseases. The therapies that exist to manage diseases associated with osteoclastogenesis are numerous and diverse. WebPI3Ks (phosphoinositide 3-kinases) regulate diverse signalling pathways involved in growth, proliferation, survival, differentiation and metabolism. In T cells, PI3Ks can be activated by a number of different receptors, including the TcR (T cell receptor), co-stimulatory receptors, cytokine receptor …

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WebNov 11, 2010 · KLF2 is required for: (1) maintaining the quiescent state of single-positive CD4+or CD8+T cells; (2) induction of T-cell trafficking markers S1P1, CD62L, β7-integrin on thymic CD4+T cells to allow for egress into peripheral lymphoid tissues; and (3) expression of chemokine receptors, such as CCR3, CCR5, and CXCR3, by autonomously or … WebApr 25, 2006 · KLF2 is induced during the maturation of single-positive T cells and is rapidly extinguished after single-positive T cell activation ( 8 ). Forced overexpression of KLF2 …

WebOct 19, 2024 · KLF2 also appears to regulate thymocyte egress and the expression of S1PR1 and CD62L, two receptors that are highly expressed by naive T cells 24, 25. Whether this …

WebThe Impact of KLF2 Modulation on the Transcriptional Program and Function of CD8 T Cells Gavin C. Preston 1, Carmen Feijoo-Carnero, Nick Schurch2, Victoria H. Cowling, Doreen A. Cantrell1* 1 ... WebKLF2 expression is induced by laminar shear stress and is inhibited by interleukin-1β.73Its up-regulation induces transcription of endothelial nitric oxide synthase (eNOS) and thrombomodulin, and inhibits transcription of vascular cell adhesion molecule-1, E-selectin, tissue factor, plasminogen activator inhibitor-1, and protease activator …

WebFeb 3, 2008 · KLF2 is first expressed in the T cell lineage at the single-positive thymocyte stage, and high expression is maintained in naive T cells 3, 4. KLF2 expression is …

WebApr 12, 2024 · KLF2, a member of the Kruppel-like factor family, has diverse roles in the immune system, and in particular plays a critical role in controlling migration of T (and B) … clover csdnWebApr 13, 2024 · KLF2 expression is associated with diverse immune infiltration cells, and may impact the breast tumor immune microenvironment by regulating dendritic cell activation. … c9300 fiber switchWebFeb 5, 2024 · Through its binding to the transcriptional coactivator p300/CBP, KLF2 is capable of preventing NF-κB/p300 interaction and subsequent activation of the vascular cell adhesion molecule-1 (VCAM-1) promoter ( 11) Furthermore, the KLF2-p300 interaction permits KLF2 binding to the endothelial nitric oxide synthase (eNOS) promoter to induce … c9300l-48t-4g-a datasheetWebJun 16, 2014 · (A) ChIP assays using antibody directed against KLF2 after lysis of wild-type CD4 + CD25 − T cells cultured under conditions that promote T-cell activation (black) vs. … clover cscWebAug 12, 2024 · The Klf2 ++ cluster was enriched for T cell migration and leukocyte cell–cell adhesion pathways, consistent with being less mature (Fig. 3e ), while the Klf2 − cluster was enriched for... clover cryptocurrency forecastWebJan 17, 2024 · KLF2/6, BTG1/2, FOXP1, and SLFN2 are regulators of quiescence. TCF7, BCL2, INFGR1, and SLAMF6 direct memory T cell fate and activity. IFN-γ and CCL5 are effector cytokines. CD69, CD25, and CD40LG are activation and costimulation receptors. (Right) Integration of VISTA with other well-established negative checkpoint regulators of … clover csiWebNov 11, 2016 · Pan-CD11c KLF2-deficiency enhances T cell activation while reducing overall T cell numbers in hypercholesterolemic mice. Splenocytes from Klf2 fl/fl (Cntrl) or Itgaxcre -Klf2 fl/fl (KO) bone marrow recipients were stained for CD3, B220, CD4, and CD8 and analyzed by flow cytometry. clover csd ymca