Ogg1 and inflammation

Author: kxtm

August undefined, 2024

Webb5 feb. 2015 · View Christopher N. Cross, Ph.D.’s profile on LinkedIn, the world’s largest professional community. Christopher N. has 8 jobs listed on their profile. See the complete ... Webb28 apr. 2016 · These findings suggested that the absence of 8-oxoG and/or OGG1 is a missing component of proinflammatory signaling in the Ogg1−/− null mice, implicating the importance of OGG1-BER in the inflammatory process. During OGG1-BER, the 8-oxoG base is excised from DNA and released to the cytoplasm where it complexes with a …

8-Oxoguanine targeted by 8-oxoguanine DNA glycosylase 1 (OGG1…

Webb5 aug. 2014 · Many components of the cell, including lipids, proteins and both nuclear and mitochondrial DNA, are vulnerable to deleterious modifications caused by reactive oxygen species. If not repaired, oxidative DNA damage can lead to disease-causing mutations, such as in cancer. Base excision repair and nucleotide excision repair are the two DNA … charlotte nc to mableton ga

TH5487, a small molecule inhibitor of OGG1, attenuates ... - PubMed

Webbproduction of versican may promote the next inflammatory response. Therefore, versican could be the first step in the amplification of the inflammatory response, and ongoing research of this molecule may help to explain the pathogenesis of inflammation. Keywords: versican; cytokines; extracellular matrix homeostasis; inflammation … Webb18 jan. 2024 · OGG1 complexed with 8-oxoG recruits transcription factors, including phosphorylated SMAD3, to pro-fibrotic gene promoters thereby facilitating gene activation. Moreover, 8-oxoG levels are elevated in lungs of mice subjected to TGFβ1-induced injury. Webb2 maj 2024 · OGG1 excises 8-oxo-7,8-dihydroguanine (8-oxo-dG) lesion on DNA that is often induced by generation of reactive oxygen species (ROS) and has been linked to mutations, cancer development, and tissue damage. charlotte nc to madrid spain

OGG1 and MUTYH repair activities promote telomeric 8

Innate Immune Responses to RSV Infection Facilitated by OGG1, …

Webb1 sep. 2024 · Considering that OGG1 may modulates oxidative stress and the inflammatory response, the current study theorizes that OGG1 is involved in the pathogenesis of PCOS via oxidative stress, inflammatory response, or a balance of the two. 2. Materials and methods 2.1. Patients and samples WebbOGG1 bound to 8-oxo(d)Gua in gene regulatory sequences promotes expression of IIR genes, and consequently exacerbates lung inflammation, histological changes, and body weight loss of experimental animals. charlotte nc to louisburg ncWebbCutoff Score for High Visceral Abdominal Fat. Table 2 shows the results of ROC analysis and the optimal cutoff score for cardio-metabolic risk factors. The VAF volume had the highest AUC for hypertension and the lowest for dyslipidemia. The AUC for hypertension also showed the highest combination of specificity and sensibility with a Younden’s … charlotte nc to lisbon portugal

"WebbOGG1 methylation levels in blood cells were measured in a prospective study of 582 US military veterans, median age 72, and followed for 13 years. High OGG1 methylation at … " - Ogg1 and inflammation

Ogg1 and inflammation

Small-molecule-mediated OGG1 inhibition attenuates pulmonary …

WebbPositional occupancy of TH5487 causes allosteric alteration of chromatin DNA by undefined mechanisms to heterochromatinize (denoted closed chromatin) blocking OGG1 recruitment of NF-κB, leading to inhibition of inflammatory gene expression. 8-oxoG, 7,8-dihydro-8-oxoguanine; NF-κB, nuclear factor κB; OGG1, 8-oxoguanine DNA … Webb8-oxoguanine DNA glycosylase 1 (OGG1) binds 8-oxoG and because Ogg1-deficient mice are resistant to acute and systemic inflammation,we hypothesized that OGG1 …

Did you know?

Webb28 feb. 2024 · In this study, a novel small molecule OGG1 inhibitor, TH5487, decreased myofibroblast transition and associated pro-fibrotic markers in fibroblast cells. In … Webb8 apr. 2024 · The study reveals that SopF can attenuate intestinal inflammation and suppress IECs expulsion to promote bacterial dissemination in mice infected with S. Typhimurium. The mechanism employed by SopF involves activating phosphoinositide-dependent protein kinase-1 (PDK1) to phosphorylate p90 ribosomal S6 kinase (RSK), …

Webb6 maj 2024 · Binding to the DNA substrate but not base excision activity is required for OGG1 to modulate pro-inflammatory gene expression. Ogg1 −/− MEF cells were transfected with plasmids expressing Flag-tagged (A) or YFP-tagged (B) wt OGG1 or site-specific mutants, and then, exposed to 20 ng/mL TNFα for 0, 30, 60, and 120 minutes. Webb9 maj 2024 · Aside from its function in DNA damage repairment, it has been reported that OGG1 takes part in the regulation of gene expression, derived from its DNA binding characteristic, and showed impacts on inflammation. Researchers believe that OGG1 could be the potential therapy target for relative disease.

WebbI dag · At least 11 distinct types are involved in BER and 8-oxoG glycosylase (OGG1) initiates repair of the most common 8-oxoG lesions in both the nucleus and mitochondria . The ... When activated, microglia can produce several factors that are toxic to neurons, such as pro-inflammatory cytokines TNFα, PGE 2, and INFγ and ROS ... Webb15 nov. 2024 · It turned out that the enzyme OGG1, apart from repairing DNA, also triggers inflammation. The inhibitor blocks the release of inflammatory proteins, such as TNF …

WebbKarolinska Institutet. jun 2012–feb 20244 år 9 månader. Science for Life Laboratory in Solna. PhD dissertation title: targeting DNA repair pathways for cancer therapy. Involved in multi-disciplinary drug discovery projects as a molecular cell biologist. Validated the cellular targets and hits from chemical screens in novel biochemical and ...

WebbBased on previous studies and the data shown in this paper, it is evident that OGG1-initiated DNA BER led to the generation of an OGG1•8-oxoG complex that functions as … charlotte nc to laurinburg ncWebb@article{Hussain2024MitochondrialOE, title={Mitochondrial OGG1 expression reduces age-associated neuroinflammation by regulating cytosolic mitochondrial DNA.}, author={Mansoor Hussain and Xixia Chu and Burcin Duan Sahbaz and Samuel Gray and Komal Pekhale and Jae-Hyeon Park and Deborah L. Croteau and Vilhelm A. Bohr}, … charlotte nc to manchester tnWebb6 dec. 2024 · OGG1 has also been shown to bind to DNA, inducing conformational changes and pro-inflammatory gene transcription (Hao et al., 2024). Cells exposed to TNF-α show an increase in the interaction between OGG1 and the promoter regions of pro-inflammatory cytokine/chemokine genes ( Hao et al., 2024 ), with OGG1 also shown to … charlotte nc to middletown ohWebb16 nov. 2024 · We developed TH5487, a selective active-site inhibitor of OGG1, which hampers OGG1 binding to and repair of 8-oxoG and which is well tolerated by mice. TH5487 prevents tumor necrosis factor-α-induced OGG1-DNA interactions at guanine … National Center for Biotechnology Information charlotte nc to melbourne australiaWebb30 dec. 2024 · OGG1 is primarily located in the cytoplasm and can enter the nucleus and mitochondria to repair damaged DNA or to exert epigenetic regulation of gene transcription. OGG1 is involved in a wide range of physiological processes, such as DNA repair, oxidative stress, inflammation, fibrosis, and autophagy. charlotte nc to mclean vaWebb16 nov. 2024 · Because 8-oxoguanine DNA glycosylase 1 (OGG1) binds 8-oxoG and because Ogg1-deficient mice are resistant to acute and systemic inflammation, we … charlotte nc to memphis tnWebb18 nov. 2024 · The inhibitor blocks the release of inflammatory proteins, such as TNF-alpha. In trials on mice with acute pulmonary disease, the researchers succeeded in dampening the inflammation. The mechanism how the OGG1 enzyme regulates such phenomenon is not yet elucidated. This enzyme looks like it turned out to be a so called … charlotte nc to matthews nc miles